CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative Chemotherapy Versus Immediate Resection in patIents With resecTable BiliarY Tract Cancers (BTC) at High Risk for Recurrence

This study is comparing two approaches for treating bile duct and gallbladder cancers that can be surgically removed: giving chemotherapy before surgery (to shrink the tumor first) versus going directly to surgery. The chemotherapy regimen being tested is a combination of cisplatin, gemcitabine, and nab-paclitaxel. **You may be eligible if...** - You are 18–74 years old - You have confirmed bile duct cancer (cholangiocarcinoma) or gallbladder cancer that has not spread to other organs and can be surgically removed - You have not had prior surgery for this cancer - Scans confirm no distant spread of disease - You are in generally good health (ECOG status 0–1) **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have mixed tumor types involving liver cancer or ampullary cancer - You have had previous treatment for bile duct or gallbladder cancer Talk to your doctor to see if this trial is right for you.