RecruitingPhase 2Phase 3NCT06050148

Faecal Microbiota Transplantation as Means of Preventing Recurrent Urinary Tract Infections


Sponsor

Helsinki University Central Hospital

Enrollment

100 participants

Start Date

Aug 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This study investigates Faecal microbiota transplantation (FMT) in prevention of recurrent urinary tract infections (UTIs) caused either by sensitive E. coli or ESBL-E. coli.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 90 Years

Inclusion Criteria3

  • Female subjects aged ≥18
  • History of recurrent UTI: at least two episodes of UTI over the past 6 months or at least three episodes over the past year, most recent episode within the past three months
  • Written informed consent

Exclusion Criteria6

  • Suspected non-compliance
  • Diagnosis of a gastrointestinal disease
  • Pregnancy
  • Immunosuppression
  • Any kind of permanent urinary catheter or intermittent urinary catheterization
  • Any other criteria which, in the investigator's opinion, would compromise the ability of the subject to participate in the study, the subject's well-being, or the outcome of the study

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Interventions

BIOLOGICALFeacal microbial transplantation (FMT)

Feacal microbial transplantation (FMT)

OTHERPlacebo transplantation (PT)

Transplantation with coloured 0,9% NaCl-solution


Locations(1)

Meilahti Vaccine Research Center, Helsinki University Central Hospital

Helsinki, Finland

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NCT06050148


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