RecruitingNot ApplicableNCT06052033

Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection

The Effect of 5-aminolaevulinic Acid Photodynamic Therapy Versus C02 Laser in the Treatment of Persistent Cervical Low-grade Squamous Intraepithelial Lesions With High-risk HPV Infection:A Non-randomized Controlled Trail Study

Sponsor

First Affiliated Hospital of Wenzhou Medical University

Enrollment

40 participants

Start Date

Sep 11, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Non-RCT clinical trial comparing 5-ALA photodynamic therapy and CO2 laser for persistent high-risk HPV-related low-grade cervical lesions.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study compares two treatments for low-grade cervical cell changes (pre-cancerous lesions) caused by persistent high-risk HPV infection: photodynamic therapy using a light-activated drug (5-ALA) versus CO2 laser treatment. Both aim to destroy abnormal cells and clear the HPV infection. **You may be eligible if...** - You are between 18 and 65 years old with a history of sexual activity - You have tested positive for the same high-risk HPV strain for more than 1 year - You have been diagnosed with low-grade cervical changes (LSIL) on biopsy confirmed more than 1 year ago - You have not used any HPV-related treatments in the past 3 months **You may NOT be eligible if...** - You have high-grade cervical changes (HSIL or CIN 2/3) or cervical cancer - You have recently used other HPV treatments - You have significant health conditions affecting major organs - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURECO2

CO2 laser treatment is a surgical procedure that employs a high-powered carbon dioxide laser beam to precisely ablate cervical lesions. The laser is applied with a depth of 7-10mm and a width of 3-5mm beyond the lesion area in a single session. This intervention aims to address persistent low-grade cervical lesions associated with high-risk HPV infection.