Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis
Comparison of Conventional Non-Invasive Ventilation and Neurally-Adjusted Ventilatory Assistance (NAVA) Non-Invasive Ventilation for the Treatment of Bronchiolitis
Montefiore Medical Center
130 participants
Dec 18, 2023
INTERVENTIONAL
Conditions
Summary
This project aims to answer whether the use of a Neurally-Adjusted Ventilatory Assistance mode for non-invasive ventilation in pediatric patients with bronchiolitis results in improved comfort and reduced escalations in therapy (including intubation) when compared to using a standard mode of non-invasive ventilation. Neurally-Adjusted Ventilatory Assistance (NAVA) has been shown to result in greater synchrony then the standard mode of non-invasive ventilation. The study team hypothesizes that this improved synchrony can result in important clinical improvements when NAVA is used to treat children with bronchiolitis.
Eligibility
Inclusion Criteria2
- Patients under the age of two years old with a diagnosis of bronchiolitis presenting to the pediatric ICU
- Patient's provider believes there is equipoise between the use of NAVA or conventional non-invasive ventilation for the patient
Exclusion Criteria5
- Patients unable to utilize a nasogastric tube
- Patients with a diagnosis of chronic lung disease, cyanotic heart lesions, or congestive heart failure
- Patients with hypotonia
- Patients likely to require imminent intubation: \>0.60 Fraction of Inspired Oxygen (FiO2); Carbon Dioxide (CO2) \> 60, frequent apneas, clinician determines patient unlikely to tolerate non-invasive modality)
- Patients with hemodynamic instability, defined as the need for vasoactive medication
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Interventions
The active comparator arm will utilize a standard non-invasive mode to provide ventilation support
The experimental arm will utilize a NAVA mode to provide non-invasive ventilation support
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06053684