RecruitingNCT06057909

A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease

Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer Disease


Sponsor

Mayo Clinic

Enrollment

90 participants

Start Date

Apr 5, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals. Researchers will look at measurements of memory, thinking, brain wave and muscle activity, daily functioning, and brain scans to learn more about brain disorders such as Alzheimer disease and Lewy body disease.


Eligibility

Min Age: 50 YearsMax Age: 95 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating changes in brain structure and activity in people with Lewy body disease (a type of dementia) and Alzheimer's disease, using MRI and EEG brain scans to better understand how these diseases affect the brain and how symptoms fluctuate over time. **You may be eligible if...** - You use English as your primary language - You have been diagnosed with Lewy body disease or Alzheimer's disease by a board-certified neurologist - OR you are a healthy individual willing to participate as a comparison participant - You are willing to undergo cognitive assessments, MRI, and EEG brain scans - You are capable of giving informed consent (with caregiver assistance if needed) **You may NOT be eligible if...** - You have a condition that prevents MRI (e.g., certain metal implants) - You are unable to comply with study procedures - You do not have a diagnosis of LBD or AD and do not qualify as a healthy control Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMagnetic Resonance Imaging

Test that looks at the structure of the brain.

DIAGNOSTIC_TESTElectroencephalography

Non-invasive technique to measure brain waves

DIAGNOSTIC_TESTElectromyography

Technique to evaluate muscle activity


Locations(1)

Mayo Clinic Arizona

Scottsdale, Arizona, United States

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NCT06057909


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