RecruitingPhase 2NCT06058078

RY_SW01 Cell Injection Therapy in Active Lupus Nephritis

A Multicenter Phase I/II Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of RY_SW01cell Injection Therapy in Active Lupus Nephritis


Sponsor

Jiangsu Renocell Biotech Company

Enrollment

60 participants

Start Date

Aug 17, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

RY\_SW01 Cell Injection's preclinical research results have shown that the injection significantly improved urine biochemical indicators and tissue damage in two lupus nephritis animal models after MSC administration, with no occurrence of rejection and excellent safety. The mechanism of action of RY\_SW01 Cell Injection is relatively clear, demonstrating favorable therapeutic effects in preclinical animal models. Compared to existing conventional therapies, it has the advantages of "convenient treatment and sustained efficacy." It may help reduce the variety and quantity of drugs administered to patients and the various side effects associated with drug treatment. In some cases, it may even lead to the discontinuation of immunosuppressive drugs, reducing mortality and disability rates while improving the quality of life for patients. Its unique advantages have the potential to fundamentally change the current clinical treatment landscape and offer promising prospects for clinical application.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Basic treatment and a drug called RY_SW01 cell injection for people with lupus nephritis. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 65 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRY_SW01 cell injection

Injected RY\_SW01 allogonic umbilical cord-derived mesenchymal stem cells(UCMSCs)

DRUGBasic treatment

Drugs for LN treatment


Locations(1)

the Affiliated Drum Tower Hospital, Medical School, Nanjing University

Nanjing, Jiangsu, China

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NCT06058078


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