RecruitingNot ApplicableNCT06059157

Epileptogenic Network Visualisation With Advanced MRI


Sponsor

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Enrollment

80 participants

Start Date

Oct 25, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to improve non-invasive identification of epileptogenic networks in drug-resistant epileptic patient. The investigators aim to compare epileptogenic network identification with stereo-EEG (used as glod standard) with the identification of the same network using advanced MRI (rs-fMRI, microstructural analysis of white matter, ...). The main goals are to: 1. Compare the accuracy of network identification. 2. Analyse the effect of the MRI sequences on candidates selection and target identification. Participants will already have been selected for stereoEEG and will undergo a supplementary MRI (about 1h) with the additional MRI sequences. Follow-up MRI are scheduled for patient undergoing a second, therapeutic epileptic surgery.


Eligibility

Min Age: 3 Years

Inclusion Criteria2

  • Patient suffering from drug-resistant epilepsy
  • Patient already selected for SEEG implantation as part of their epileptic networks

Exclusion Criteria2

  • Patient excluded from SEEG (pregnant women, children too young for the procedure, patient unable to undergo the procedure)
  • Contra-indication for MRI

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Interventions

DEVICEAdvanced MRI

resting-state functional MRI, diffusion with advanced post-processing (microstructure analysis), myelin mapping


Locations(1)

Cliniques Universitaires St-Luc

Brussels, Belgium

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NCT06059157


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