RecruitingPhase 2NCT06059469

PSMA-PET/CT to Assess the Expression of Specific Membrane Antigen (PSMA) in Patients With Progressive Triple-negative Breast Cancer.

PRISMA: A Single-centre, Prospective Phase II Imaging Study Using PSMA-PET/CT to Assess the Expression of Specific Membrane Antigen (PSMA) in Patients With Progressive Triple-negative Breast Cancer.


Sponsor

Jules Bordet Institute

Enrollment

20 participants

Start Date

May 30, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is a descriptive, prospective, single centre study. This study will assess PSMA expression via the uptake of radiolabelled PSMA-ligand using PET/CT imaging in mTNBC lesions pre-identified on 18F-FDG PET/CT in order to evaluate the feasibility of molecular radionuclide therapy in refractory mTNBC using the Lutetium-177 radiolabelled PSMA.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using a special PET/CT scan (PSMA-PET/CT) to measure how much of a protein called PSMA is present in triple-negative breast cancer (TNBC) that has progressed or spread. PSMA is a protein usually associated with prostate cancer, but researchers want to know if it also appears in this type of breast cancer, potentially opening new treatment avenues. **You may be eligible if...** - You are a woman aged 18 or older - You have been confirmed to have progressive metastatic triple-negative breast cancer - You have measurable disease on standard imaging - Your general health is acceptable (ECOG 0-2) **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have had prior PSMA-targeted therapy - You have severe kidney problems preventing contrast dye use Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTGa-PSMA PET/CT

Patient undergo Ga-PSMA PET/CT prior to the start of the new drug treatment


Locations(1)

Institut Jules Bordet

Brussels, Belgium

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06059469


Related Trials