RecruitingPhase 2NCT06065813

Neoadjuvant Triprizumab and Radiotherapy in Operable Patients With Stage IIA-IIIA Non-small Cell Lung Cancer

The Efficacy and Safety of Neoadjuvant Triprizumab and Radiotherapy in Operable Patients With Stage IIB-IIIA Non-small Cell Lung Cancer


Sponsor

Northern Jiangsu People's Hospital

Enrollment

20 participants

Start Date

Aug 8, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Neoadjuvant Triprizumab and Radiotherapy in Operable Patients With Stage IIA-IIIA Non-small Cell Lung Cancer


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether adding an immunotherapy drug (triprizumab, an anti-PD-1 antibody) to radiation therapy before surgery improves outcomes for people with early-stage non-small cell lung cancer (NSCLC). Giving treatment before surgery is called neoadjuvant therapy. **You may be eligible if...** - You are 18–70 years old - You have confirmed resectable (operable) stage IIA–IIIA non-small cell lung cancer - You have not had any prior treatment for this cancer - You have at least one measurable tumor - Your general health and organ function are adequate (good performance status and blood/lab values) **You may NOT be eligible if...** - Your cancer is at a more advanced or earlier stage - You have already received treatment for this cancer - Your health or organ function doesn't meet the minimum requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGToripalimab

200 mg Toripalimab intravenously every 3 weeks 3 doses of Toripalimab before operation 14 doses of Toripalimab 30 days after operation

RADIATIONConventional segmental radiotherapy

the does of radiation will be 40-45Gy. The day of the first dose of Toripalimab and the first day of radiation must be the same day.

OTHERopreation

The operable patients will accept radical operated in 28-42 days after the third dose of Toripalimab


Locations(1)

People's hospital of northern jiangsu

Yangzhou, Jiangsu, China

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NCT06065813


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