RecruitingNCT06067347

A Global Study of the PETAL Consortium

Integration of Machine Learning and Genomics to Predict Outcomes for Newly Diagnosed, Relapsed and Refractory Mature T-cell and NK/T-cell Lymphomas: a Global Study of the PETAL Consortium


Sponsor

Massachusetts General Hospital

Enrollment

1,200 participants

Start Date

Jan 5, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to correlate molecular alterations with outcomes including overall survival (OS), progression-free survival (PFS), response rates for patients with a new diagnosis, primary refractory or relapse, of mature T-cell and NK-cell neoplasms (TNKL). We hypothesize that machine learning can be leveraged to uncover distinct genetic vulnerabilities that underlie treatment response and resistance for patients with TNKL, thus moving towards personalized treatment solutions.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This global study through the PETAL Consortium collects data and tests treatments for people with mature T-cell and NK-cell lymphomas (a group of rare and aggressive blood cancers). The study focuses on peripheral T-cell lymphoma (PTCL) subtypes, which are notoriously difficult to treat. **You may be eligible if...** - You have a confirmed diagnosis of a mature T-cell or NK-cell neoplasm (blood cancer) - Your cancer is untreated, relapsed, or no longer responding to treatment - Most PTCL subtypes are eligible **You may NOT be eligible if...** - You have T-cell large granular lymphocytic leukemia - You have cutaneous T-cell lymphoma (e.g., mycosis fungoides, Sézary syndrome) - You have primary cutaneous CD30+ disorders - You are a minor, unable to consent, pregnant, or incarcerated Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(14)

City of Hope

Duarte, California, United States

University of Colorado

Denver, Colorado, United States

Moffitt Cancer Center

Tampa, Florida, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Mayo Clinic

Rochester, Minnesota, United States

Hackensack University Medical Center

Hackensack, New Jersey, United States

OhioHealth

Columbus, Ohio, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

University of Virginia

Charlottesville, Virginia, United States

Royal Adelaide Hospital

Adelaide, South Australia, Australia

Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia

Kyoto University

Kyoto, Japan

University of Cape Town

Cape Town, South Africa, South Africa

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06067347