Effect of Lactobacillus Johnsonii or White Pomegranate Extract on the Vaginal Health
Effect of Oral Probiotic Heat-killed Lactobacillus Johnsonii TCI250 or White Pomegranate Extract on the Vaginal Flora
Chung Shan Medical University
150 participants
Apr 4, 2022
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to explore the effect of Lactobacillus johnsonii and white pomegranate extract on female bacterial status, it aims to answer are: * Evaluate Lactobacillus johnsonii TCI250 probiotics or white pomegranate extract in regulating female vaginal bacteria and improving vaginal health. * Evaluate Lactobacillus johnsonii TCI250 probiotics or white pomegranate extract in regulating inflammation. Participants will be randomly assigned to placebo (n = 50), probiotic heat-killed Lactobacillus johnsonii TCI250 group (n = 50) and white pomegranate extract group (n = 50) for 8 weeks. Researchers will compare the vaginal flora and inflammation.
Eligibility
Inclusion Criteria3
- Females aged 20-45
- Nugent score ≥ 4
- Menstrual cycle of 28-60 days
Exclusion Criteria4
- Pregnant or lactating women
- Antibiotic usage
- Other reproductive-related inflammatory diseases (e.g., candidiasis, gonorrhea, chlamydia infection)
- Allergy to probiotics or White Pomegranate-related components
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Interventions
Group A: Placebo; Group B: heat-killed Lactobacillus johnsonii TCI250; Group C: White pomegranate extract, dosage of 500mg for 8 weeks.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06069531