RecruitingPhase 1NCT06069791

Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1

Anesthetic Greater Occipital Nerve Blockade in Veterans With Post-Traumatic Headache: Sub-study 1


Sponsor

Yale University

Enrollment

12 participants

Start Date

Jan 26, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each.


Eligibility

Min Age: 18 Years

Inclusion Criteria5

  • United States Military Veterans within VA Connecticut Healthcare System
  • Chronic post-traumatic headache per ICHD-3 criteria (i.e., headaches are continuing to occur three months after the head injury)
  • At least two headache days per week
  • MRI brain scan completed within the past 3 months if chronic PTH for less than one year, within the past year if chronic PTH for less than 5 years, and within 5 years if chronic PTH for more than 10 years
  • Review of MRI and the medical record does not reveal another source for headache

Exclusion Criteria5

  • Skull defect
  • Other contraindication to bupivacaine
  • Allergy or adverse reaction (e.g., rash, cardiac effects) to amide anesthetics, such as lidocaine
  • Instruction from clinician to avoid amide anesthetics, such as lidocaine
  • Pregnant or lack of adequate birth control

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Interventions

DRUGBupivacaine Injection

subcutaneous injection around bilateral greater occipital nerves


Locations(1)

VA Connecticut Healthcare System

West Haven, Connecticut, United States

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NCT06069791


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