RecruitingNot ApplicableNCT06077019
Role of Lung Function for Exercise Capacity in Well-trained Individuals
Role of Lung Function, Airway Inflammation and Bronchial Hyper Reactivity for Exercise Capacity in Well-trained Individuals
Sponsor
Morten Hostrup, PhD
Enrollment
60 participants
Start Date
Oct 3, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of the project is to investigate exercise performance in humans following prolonged inhalation of beta2-agonists vilanterol + fluticasone furoate or indacaterol + mometasone furoate
Eligibility
Min Age: 18 YearsMax Age: 39 Years
Inclusion Criteria3
- Age 18-39
- Physically active > 5 h weekly
- Maximal oxygen consumption classified as high or very high
Exclusion Criteria10
- Diagnosed with severe asthma and been in treatment with long-acting beta2-agonist/corticosteroid
- ECG abnormality
- ACQ score > 1.5
- Severe bronchial hyperreactivity as determined by mannitol test
- FEV1/FVC ratio < 0.7 determined with spirometry
- Chronic illness determined to be a potential risk for participant during study
- In chronic treatment with medication that may interfere with study results
- Pregnancy
- Smoker
- Blood donation during the past 3 months
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Interventions
DRUGVilanterol and Fluticasone Furoate
Participants inhale 25 µg vilanterol + fluticasone furoate daily
DRUGIndacaterol and Mometasone Furoate
Participants inhale 125 µg indacaterol + mometasone furoate daily
DRUGPlacebo
Participants inhale placebo daily
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06077019
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