RecruitingNot ApplicableNCT06080698

Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial


Sponsor

Johns Hopkins University

Enrollment

1,030 participants

Start Date

Feb 22, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy for the treatment of Gram-Negative BloodStream Infection (GN-BSI) is as effective but safer than remaining on intravenous (IV) antibiotic therapy for the duration of treatment.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Intravenous Antibiotics and a drug called Oral Antibiotics for people with gram-negative bacteremia. The study is currently recruiting participants at 11 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIntravenous Antibiotics

Participants will continue to receive intravenous antibiotics until the completion of the treatment course

DRUGOral Antibiotics

Participants will transition to oral antibiotics at the time of randomization and will continue oral antibiotics until the completion of the treatment course


Locations(11)

University of California, San Francisco

San Francisco, California, United States

Denver Health Hospital Authority

Denver, Colorado, United States

University of Maryland Medical Center

Baltimore, Maryland, United States

Johns Hopkins University Hospital Systems

Baltimore, Maryland, United States

Mayo Clinic

Rochester, Minnesota, United States

Rutgers-RWJ University Hospital

New Brunswick, New Jersey, United States

Duke University

Durham, North Carolina, United States

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Houston Methodist

Houston, Texas, United States

Carilion Clinic

Roanoke, Virginia, United States

View Full Details on ClinicalTrials.gov

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NCT06080698


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