Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders

This study tests whether sertraline (a common antidepressant/anti-anxiety medication) can reduce anxiety symptoms in children and teenagers who have neurodevelopmental disorders such as autism spectrum disorder (ASD), ADHD, Fragile X syndrome, or tic disorders. **You may be eligible if...** - You are between 8 and 17 years old - You have been diagnosed with ASD, ADHD, tic disorders, Fragile X, tuberous sclerosis, or 22q11 deletion syndrome - You also have a significant anxiety disorder (such as separation anxiety, social anxiety, or generalized anxiety) - Your anxiety is rated as at least moderately severe by a clinician - Your current medications have been stable for at least one month **You may NOT be eligible if...** - You are currently taking another SSRI antidepressant - You have previously tried sertraline without benefit or with significant side effects - You have tried and failed more than two SSRIs - You are pregnant or sexually active without adequate contraception - You have HIV, hepatitis, hemophilia, or a serious medical condition that may interact with sertraline - You are taking MAO inhibitors or pimozide Talk to your doctor to see if this trial is right for you.