A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers

This study is looking at whether special MRI scans and tumor samples can help doctors better understand and predict how head and neck cancer responds to treatment. Researchers want to see if certain biological markers in tumors match what they can see on advanced imaging scans. **You may be eligible if...** - You are 18 or older - You have been diagnosed with squamous cell carcinoma of the head and neck, confirmed by biopsy - Your tumor or lymph node is larger than 3 cm - You are planned to have surgery or radiation (with or without chemotherapy) to treat your cancer - You are able to lie flat comfortably for about 1 hour for MRI scans - Your kidneys are functioning adequately **You may NOT be eligible if...** - You cannot have an MRI (e.g., pacemaker, certain metal implants) - You have had another solid tumor treated within the last 5 years - You are pregnant - You have a known allergy to gadolinium contrast dye - You have a blood clotting disorder that cannot be corrected Talk to your doctor to see if this trial is right for you.