RecruitingNot ApplicableNCT06085781
A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers
HN-BIO: A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers
Sponsor
University Health Network, Toronto
Enrollment
60 participants
Start Date
Jan 29, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to explore biomarker development in patients with newly diagnosed Head and neck squamous cell carcinoma (HNSCC) receiving curative therapy.
Eligibility
Min Age: 18 Years
Inclusion Criteria9
- Age \>/= 18 years
- Histologically proven Head and Neck Squamous Cell carcinoma
- Primary or nodal disease \> 3cm for biomarker imaging
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
- Planned for curative surgery or (chemo)radiotherapy
- Willingness to undergo repeat MRI imaging
- Able to receive and understand verbal and written information regarding study and able to give written informed consent
- Adequate renal function: Calculated creatinine clearance \>/= 30ml/min
- Be able to lie comfortably on back for 1 hour
Exclusion Criteria6
- As judged by investigator evidence of systemic disease that makes unsuitable for study
- Contra-indication for serial MRI scans
- Previous solid tumor treated within last 5 years
- Pregnancy
- History of gadolinium contrast allergy
- Non-reversible clotting abnormality
Interventions
OTHERfMRI
Functional Magnetic Resonance Imaging
OTHEROral Pimonidazole
200 mg and 300 mg tablets
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06085781
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