Speech-in-noise Perception in Autism and Fragile X
Cortical Mechanisms of Speech in Noise Perception in Autism and Fragile X Syndrome
Children's Hospital Medical Center, Cincinnati
60 participants
Nov 10, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise? Participants will complete the following: * hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.
Eligibility
Inclusion Criteria14
- normal audiograms (PTA ≤ 20 dB HL)
- corrected 20/20 vision (Snellen chart)
- no history of premature birth (prior to 36 weeks gestation)
- no medications known to affect EEG signal
- English as the first language
- Inclusion for the Autism group requires the following:
- \) diagnosis of Autism Spectrum Disorder either based on previous ADOS administration and developmental history, or confirmed via ADOS and developmental history
- Inclusion for the Autism + FXS group requires the following:
- Documented PCR/Southern Blot genetic testing confirming full mutation FXS
- Diagnosis of Autism Spectrum Disorder, per Autism group.
- Inclusion for the Typically Developing group requires the following:
- no siblings or parents with an Autism Spectrum Disorder or Fragile X Syndrome
- no current neurological or psychiatric diagnoses
- IQ over 75
Exclusion Criteria2
- Hearing loss or uncorrected vision loss
- history of premature birth (prior to 36 weeks gestation)
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Interventions
Event related potentials are compared between frequent and infrequent speech sounds (i.e., "ba" vs "da").
Locations(1)
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NCT06088589