RecruitingNot ApplicableNCT06089850

Psychological Impact of Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation on Donors

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

50 participants

Start Date

Jan 22, 2024

Study Type

INTERVENTIONAL

Conditions

Transplantation Haplo-identical Transplantation

Summary

Allogeneic hematopoietic stem cell transplantation (allo-HSC) is currently one of the only curative treatments for haematological malignancies with a poor prognosis, the realization of which presupposes the identification and availability of a compatible donor. In recent years, haploidentical transplants have been developed, a reliable alternative for patients who do not have 100% compatible donors. The development of haplo-identical transplants leads to an exponential increase in the use of intra-family donation. Intrafamilial donation of hematopoietic stem cells (HSC) has the advantages of lower financial cost and faster availability of the graft, thus avoiding the risk of relapse before the procedure. Nevertheless, intrafamilial donation raises clinical and ethical questions. Indeed, the psychological impact of intra-family donation on the donor cannot be overlooked. Thus, in the context of the development of haplo-identical transplants, measuring the impact of donation on donors (ascendants and descendants) will make it possible to assess the relevance of taking psychosocial aspects into consideration in the choice of donors, to assess the psychological impact of haplo-identical donation and to offer psychological support adapted to donors.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the psychological impact on people who donated their stem cells to a half-matched (haploidentical) family member for a bone marrow transplant. Donating stem cells can be stressful, and researchers want to better understand the emotional and mental well-being of these donors over time. **You may be eligible if...** - You donated stem cells (bone marrow or blood) to a half-matched family member (parent or child) for a transplant - You are an adult (18 or older) - You are living in mainland France and received care at one of the participating centers - You are covered by the French social security system - You can read and write in French **You may NOT be eligible if...** - You cannot understand or communicate in French sufficiently Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHEREvaluate the evolution of the psychic state of the donors (ascendants and descendants), by means of questionnaires, within the framework of haplo-identical allograft.

Donors are included in the study during the pre-donation assessment. Completion of questionnaires + socio-demographic data CSH collection visit (V1): Visit at which donors are collected for CSH donation. Completion by the donor of the questionnaires Follow-up of donors at D90 (+/-7) post V1, D180 (+/-15D) post V1 and D360 (+/-15D) post V1. The donors participating in the study will complete the scales/questionnaires D360: Completion by the donor of the questionnaires + semi-structured interview by telephone if accepted by the participant