RecruitingNCT06090617

Water and Electrolytes Content in HYpertension (WHYSKI) in the SKIn

The Water and Electrolytes Content in Salt-dependent Human HYpertension (WHYSKI) in the SKIn Before and After Surgical Cure of Primary Aldosteronism


Sponsor

University Hospital Padova

Enrollment

35 participants

Start Date

Jan 1, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

WHYSKI is a prospective within-patient observational clinical study designed to test the hypothesis that alterations of Na+, K+, water, and the lympho-angiogenetic transcription factor Tonicity Enhancing Binding Protein (TonEBP) mRNA take place in the interstitium of the skin compartment of patients with arterial hypertension due to primary aldosteronism in whom hypertension can be surgically cured.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how salt (sodium) and water are stored in the skin of people with high blood pressure, particularly those with a specific type called primary aldosteronism (PA), where the adrenal gland overproduces a hormone that causes salt retention. Researchers will use a specialized MRI technique to measure sodium in the skin and see if it differs from people with regular high blood pressure. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with primary aldosteronism (confirmed by blood tests and adrenal vein sampling) OR you have essential hypertension (regular high blood pressure, either on medications or confirmed by blood pressure monitoring) **You may NOT be eligible if...** - You have secondary hypertension from causes other than primary aldosteronism (for the PA group) - You have a condition that prevents MRI scanning (e.g., pacemaker, metal implants) - You are pregnant - You have severe kidney or liver disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURESkin Biopsy

Skin biopsies were obtained in all recruited patients.

PROCEDUREVideo-laparoscopic adrenalectomy

Video-laparoscopic adrenalectomy in those with unilateral PA. (PA group 1)


Locations(1)

Azienda Ospedale Università di Padova

Padua, Italy

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NCT06090617


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