RecruitingNCT06094569

Medical Imaging Screening for Posterior-circulation Ischemic Stroke

Medical Imaging Screening for Posterior-circulation Ischemic Stroke：a Multicentre,Imaging-based,Prospective Cohort Study

Sponsor

Tianjin Huanhu Hospital

Enrollment

1,000 participants

Start Date

Jun 1, 2019

Study Type

OBSERVATIONAL

Conditions

Endovascular Thrombectomy

Summary

Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment. We wanted to evaluate preoperative imaging to screen patients with a good prognosis from mechanical embolization. We assess the degree of ischemia by defining the pons-midbrain-medulla index (PMMI) and correlate the preoperative PMMI with the clinical prognosis of postoperative patients to verify the validity of PMMI in predicting the clinical prognosis of patients with embolization.

Eligibility

Inclusion Criteria3

Patient admitted from Jun. 1st 2019 to Jan. 1st 2029;
Patients with acute ischemic stroke recently；
Symptoms persisted at admission, and MRI (including DWI) confirmed acute ischemic vertebrobasilar artery occlusion in the posterior circulation:（single right or left intracranial branch of vertebral artery occlusion ; single basilar occlusion ; both two vertebral arterys and basilar artery）；

Exclusion Criteria1

Patiens can not meet the MRI examination conditions(with absolute and relative contraindications).

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Interventions

PROCEDUREEndovascular Therapy

Endovascular therapy, as an adjunct to standard stroke therapy, may be beneficial for a very select population of patients who present with an acute ischemic stroke and have a proven large, proximal occlusion on imaging. Endovascular therapy includes any one or more of the following: Intra-arterial thrombolytic therapy, aspiration, stent retrieval, or a combination of multiple mechanical devices