RecruitingPhase 4NCT06094816

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study


Sponsor

University of Delaware

Enrollment

120 participants

Start Date

Mar 5, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.


Eligibility

Min Age: 40 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This MRI brain study is looking at how specific proteins in the brain that regulate salt and fluid balance may contribute to high blood pressure that is sensitive to salt intake. Healthy volunteers are needed to help establish baseline comparisons for people with salt-sensitive hypertension. **You may be eligible if...** - You are between 40 and 60 years old - Your blood pressure is in the normal-to-mildly elevated range (100/60 to 140/90 mmHg) - Your BMI is between 18.5 and 30 - Your potassium level and general health are normal - You have no history of heart, kidney, metabolic, or neurological disease **You may NOT be eligible if...** - You are outside the 40–60 age range - You have high or low blood pressure, abnormal BMI, or abnormal potassium - You have a history of cancer, cardiovascular, respiratory, psychiatric, or neurological disease - You are currently using tobacco, nicotine, or hormone replacement therapy - You are pregnant or nursing - You have a diagnosed anxiety, depression, or other psychiatric condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFurosemide (Diuretic)

The diuretic furosemide will be given during a 3% hypertonic saline infusion to examine blockade of the NKCC2.

OTHERHypertonic Saline Infusion

3% Hypertonic saline infusion to acutely increase sodium and osmolality


Locations(1)

University of Delaware

Newark, Delaware, United States

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NCT06094816