DBS for Depression

This study is testing deep brain stimulation (DBS) — a surgical procedure that implants small electrodes in the brain to deliver electrical pulses — as a treatment for severe, treatment-resistant depression or bipolar disorder. It is intended for people whose depression has not improved with many years of medications, therapy, or other treatments. **You may be eligible if...** - You are between 18 and 65 years old - You have a diagnosis of major depressive disorder or bipolar disorder (I or II) - Your depression is severe and has lasted at least 5 years since the first episode, with at least 4 episodes or a chronic course - You score at least 21 on standardized depression rating scales - You have significant disability in daily functioning - You have tried multiple treatments without adequate relief **You may NOT be eligible if...** - You are unable to give informed consent - You have medical conditions making brain surgery too risky - You have active suicidal plans requiring immediate intervention - You have substance use disorders or other conditions incompatible with the procedure Talk to your doctor to see if this trial is right for you.