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RecruitingNCT06096805

Prediction of Placental Fetal Growth Restriction in High Risk Population (PoPFGR)

Sponsor

Shanghai First Maternity and Infant Hospital

Enrollment

2,000 participants

Start Date

Aug 10, 2023

Study Type

OBSERVATIONAL

Conditions

Fetal Growth Retardation

Summary

This study intends to prospectively enroll high-risk pregnant women to establish a multicenter cohort. By combining maternal basic characteristics, medical history, early pregnancy ultrasound, and biological markers, we aim to construct a joint predictive model for MVM-FGR.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 45 Years

Inclusion Criteria13

  • Pregnant women with gestational age of \<14 weeks
  • Maternal age between 18 and 45 years old
  • With at least one of FGR high risk factors:
  • Maternal age \>40 years
  • Nulliparous, Maternal age \>38 years
  • Previous pregnancy with FGR, PE or placental abruption
  • Maternal medical history of chronic hypertension, diabetes mellitus, chronic nephritis or autoimmune diseases (such as SLE or APS)
  • Recurrent spontaneous abortion (RSA) \> 3 times with unknown causes
  • Or with at least two of the following FGR high risk factors:
  • Maternal age 35\~40 years
  • BMI ≥ 28 kg/m2 or BMI \< 18.5 kg/m2
  • Conception with assisted reproductive technology
  • Interval from previous delivery: \> 5 years or \< 6 months

Exclusion Criteria1

  • Presence of fetal genetic abnormalities or severe structural abnormalities in prenatal ultrasound or genetic testing.
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Locations(1)

Shanghai First Maternity and Infant Hospital

Shanghai, Shanghai Municipality, China

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NCT06096805

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