Progesterone Therapeutic Regimen Plus Statins in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia

This study is testing whether adding statins (cholesterol-lowering drugs commonly used for heart disease) to standard progesterone hormone therapy can improve the chance of curing or controlling early-stage endometrial cancer (uterine cancer) or pre-cancerous uterine tissue in young women who want to preserve their ability to have children. **You may be eligible if...** - You are 45 years old or younger - You have been diagnosed with either atypical endometrial hyperplasia (pre-cancerous thickening of the uterine lining) or early-stage, well-differentiated endometrial cancer (Stage IA, confined to the uterus without deep invasion) - You strongly wish to preserve your fertility - You have not yet used progesterone treatment, or your cancer has not fully responded to progesterone treatment - Your liver and kidney function are adequate **You may NOT be eligible if...** - Your cancer has spread outside the uterus (cervix, pelvis, or distant metastases) - You have had prior cancer in the uterus or elsewhere that would complicate treatment - You have severe liver or kidney disease - You are allergic to the study medications or have contraindications to statins or progesterone Talk to your doctor to see if this trial is right for you.