NOL Guided Analgesia During Elective Laparoscopic Surgery Under General Anesthesia
Ιntraoperative Administration of Opioids Guided by the Nociception Level Index NOL in Elective Laparoscopic Surgeries Under General Anesthesia: Effect on Opioid Consumption, Post-operative Pain and Patient Recovery
Attikon Hospital
50 participants
Apr 20, 2023
INTERVENTIONAL
Conditions
Summary
The aim of this study is to investigate the hypothesis that the intraoperative use of the nociception level index NOL can reduce opioid consumption in adult patients undergoing elective laparoscopic surgeries under general anesthesia, as well as to explore its effect on post-operative pain and patient recovery.
Eligibility
Inclusion Criteria1
- Adult patients undergoing planned laparoscopic surgery under general anesthesia.
Exclusion Criteria10
- Emergency surgery.
- Pregnancy.
- Drug or alcohol abuse in the last 6 months.
- Chronic opioid use or patients with chronic pain.
- Serious comorbidity \[cardiac disease (atrial fibrillation, ventricular arrhythmias), liver or kidney disease\]
- Obesity (BMI >35).
- Permanently implanted pacemaker.
- Patients with CNS disease.
- Allergy to any of the study drugs.
- Patients receiving anticholinergics agonists, α2-adrenergic agonists, β1-adrenergic antagonists, antiarrhythmic drugs.
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Interventions
If a NOL value \>25 persists for \>1 minute a bolus of iv fentanyl 0.5mcg/kg will be given and reassessment of the NOL value will continue every 5 minutes. If NOL index value: 10-25 is not reached within 10 minutes, fentanyl 0.5mcg/kg iv is re-administered.
Bolus doses of iv fentanyl 0.5 mcg/kg will be administered based on the judgment of the anesthesiologist in charge.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06104059