Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

This study tests whether using real-time MRI scans to adapt and personalize radiation therapy during treatment leads to better outcomes for patients with newly diagnosed high-grade brain tumors (glioblastoma and related cancers). **You may be eligible if...** - You are 18 or older with a confirmed high-grade glioma (glioblastoma, anaplastic astrocytoma, or anaplastic oligodendroglioma) - You have a good functional status (Karnofsky score of 70 or above) - You are planned to receive standard radiation therapy (about 60 Gy in 30–33 sessions, or a shorter course if over 65) - You have had a negative pregnancy test if applicable **You may NOT be eligible if...** - You have already received radiation or other treatment for this tumor (aside from biopsy or removal surgery) - There is evidence of cancer spread outside the brain - You have had another cancer in the last 2 years (non-melanoma skin cancer is OK) Talk to your doctor to see if this trial is right for you.