A Phase I Clinical Study of SHR-2005 Intravesical Instillation in the Treatment of Intermediate and High-risk Non-muscle Invasive Bladder Cancer (NMIBC)

This study tests SHR-2005, a new drug placed directly into the bladder (intravesical instillation), as a treatment for bladder cancer that has not yet invaded the muscle wall (called non-muscle invasive bladder cancer, or NMIBC). This is a Phase I safety study. **You may be eligible if...** - You are 18 or older - You have been diagnosed with intermediate or high-risk non-muscle invasive bladder cancer - You have good overall physical health and organ function - You have a life expectancy of at least 2 years **You may NOT be eligible if...** - You had bladder surgery or radiation within the last 2 weeks - You had a severe infection in the last 2 weeks - You had major surgery or serious trauma in the last 4 weeks - You are currently in another clinical trial or recently ended one - You have a history of serious heart or brain vascular disease - You have previously received certain immune-stimulating antibody therapies Talk to your doctor to see if this trial is right for you.