The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery
The Dose Effect of Activated Clotting Time and Tranexamic Acid on Bleeding in Adult Cardiac Surgery
Taichung Veterans General Hospital
150 participants
Feb 8, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery. The main questions it aims to answer are: 1. Does higher dose of tranexamic acid reduce the amount of bleeding and blood transfusion? 2. Does lower ACT level during cardiac surgery reduce the amount of bleeding and blood transfusion? Participants will divided into four groups which have different tranexamic acid dose and ACT level during cardiac surgery to see if there is any different in the amount of bleeding and blood transfusion.
Eligibility
Inclusion Criteria1
- adult, cardiac surgery with cardiopulmonary bypass
Exclusion Criteria8
- pregnant
- emergency procedure
- immune compromised
- aortic surgery
- end-stage renal disease
- liver disease
- critical status
- incomplete clinical data
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Interventions
tranexamic acid will be used in two different doses (50mg/kg vs 20mg/kg). the tranexamic acid pump will start from the begin of anesthesia until all dose is administrated.
Locations(2)
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NCT06109155