Impact of Long-acting Bronchodilator- -Corticoid Inhaled Therapy on Ventilation, Lung Function and Breathlessness

This study tests whether a combination inhaled therapy (a long-acting bronchodilator plus corticosteroid) improves breathing, lung function, and the sensation of breathlessness in patients with moderate-to-severe COPD (chronic obstructive pulmonary disease). Researchers use specialized breathing tests and lung scans to measure improvements. **You may be eligible if...** - You are between 40 and 75 years old with confirmed COPD (based on breathing tests) - You have smoked for more than 10 pack-years - You experience significant breathlessness day-to-day **You may NOT be eligible if...** - You have asthma or asthma-COPD overlap - You had a respiratory infection or COPD flare-up in the last 6 weeks (or 2 months if it led to hospitalization) - You have significant heart problems (recent heart attack, severe heart failure, serious arrhythmia) - You have severe kidney or liver problems - You are pregnant or breastfeeding - You have had any cancer in the last 5 years Talk to your doctor to see if this trial is right for you.