RecruitingPhase 2NCT06116682

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

A Phase II Study of Amivantamab SC (Subcutaneous) in Participants With MET Amplification-Positive Stage IV or Recurrent Non-Small Cell Lung Cancer (LUNG-MAP SUB-STUDY)

Sponsor

SWOG Cancer Research Network

Enrollment

88 participants

Start Date

Nov 19, 2024

Study Type

INTERVENTIONAL

Conditions

Lung Non-Small Cell Carcinoma

Summary

This phase II Expanded Lung-MAP treatment trial tests how well amivantamab-subcutaneous (SC) works in treating patients patients with MET amplification non-small cell lung cancer. Amivantamab-SC is a drug that reduces extra copies of the MET gene, a change present in your tumor. Giving amivantamab-SC may lower the chance of the growth or spread of advanced non-small cell lung cancer that has extra copies of the MET gene in the tumor.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is part of the LUNG-MAP master protocol and tests a targeted drug called tepotinib in patients with advanced non-small cell lung cancer (NSCLC) whose tumors have extra copies of the MET gene — a genetic change that drives cancer growth and treatment resistance. **You may be eligible if:** - You have advanced non-small cell lung cancer that has been confirmed by tissue biopsy - Your tumor has MET gene amplification (too many copies of the MET gene), confirmed by a specific genetic test - You have measurable disease visible on CT or MRI scan - You have been assigned to this sub-study through the LUNG-MAP protocol **You may NOT be eligible if:** - Your tumor does not have MET amplification - You have not been enrolled in the LUNG-MAP study - You have certain other health conditions or prior treatments that conflict with study requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALAmivantamab

Given amivantamab-SC

PROCEDUREBiospecimen Collection

Undergo collection of blood samples

PROCEDUREComputed Tomography

Undergo CT scan

PROCEDUREMagnetic Resonance Imaging

Undergo MRI

Locations(213)

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, United States

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Sutter Auburn Faith Hospital

Auburn, California, United States

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, United States

Palo Alto Medical Foundation-Fremont

Fremont, California, United States

UC San Diego Moores Cancer Center

La Jolla, California, United States

Loma Linda University Medical Center

Loma Linda, California, United States

Memorial Medical Center

Modesto, California, United States

Palo Alto Medical Foundation Health Care

Palo Alto, California, United States

Eisenhower Medical Center

Rancho Mirage, California, United States

Sutter Roseville Medical Center

Roseville, California, United States

Sutter Medical Center Sacramento

Sacramento, California, United States

University of California Davis Comprehensive Cancer Center

Sacramento, California, United States

California Pacific Medical Center-Pacific Campus

San Francisco, California, United States

Mills Health Center

San Mateo, California, United States

Sutter Pacific Medical Foundation

Santa Rosa, California, United States

Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, United States

Sutter Solano Medical Center/Cancer Center

Vallejo, California, United States

Rocky Mountain Regional VA Medical Center

Aurora, Colorado, United States

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, United States

Memorial Hospital North

Colorado Springs, Colorado, United States

Poudre Valley Hospital

Fort Collins, Colorado, United States

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, United States

UCHealth Greeley Hospital

Greeley, Colorado, United States

Medical Center of the Rockies

Loveland, Colorado, United States

Bayhealth Hospital Kent Campus

Dover, Delaware, United States

Bayhealth Hospital Sussex Campus

Milford, Delaware, United States

Malcom Randall Veterans Administration Medical Center

Gainesville, Florida, United States

Northeast Georgia Medical Center-Gainesville

Gainesville, Georgia, United States

Hawaii Cancer Care Inc - Waterfront Plaza