RecruitingPhase 1NCT06122610

Using Novel Imaging to More Safely Treat Neuroendocrine Tumors

Dosimetry-Guided 177Lu-DOTATATE Treatment Planning Using 64Cu-DOTATATE as a Surrogate


Sponsor

University of Wisconsin, Madison

Enrollment

10 participants

Start Date

Mar 7, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this research is to determine if DetectnetTM PET/CT can be used to make Lutathera therapy safer for patients with neuroendocrine cancer. Participants will: * Complete two phases involving 6 visits * Undergo additional research PET/CT, and possibly SPECT/CT scans


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Candidates for 177Lu-DOTATATE (Lutathera) treatment for somatostatin receptor-positive neuroendocrine tumor

Exclusion Criteria3

  • Unable to lie flat during or tolerate PET/CT or SPECT/CT
  • Known incompatibility to CT. SPECT, or PET scans
  • Unlikely to comply with study procedures, restrictions and requirements and judged by the investigator that the participant is not suitable for participation in the study

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Interventions

DEVICESingle Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT)

SPECT/CT will be performed after first cycle of Lutathera® treatment

DEVICEPhoton Emission Tomography / CT (PET/CT)

PET/CT will be performed after 64Cu-DOTATATE and Lutathera® treatment

DRUG64Cu-Dotatate

Standard of care administration of radioactive drug for PET/CT

DRUG177Lu-Dotatate

Standard of care administration of radioactive drug for PET/CT and SPECT/CT


Locations(1)

University of Wisconsin - Madison

Madison, Wisconsin, United States

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NCT06122610


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