RecruitingPhase 3NCT06123156

Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer

Intérêt de la rééducation érectile précoce Par Sildénafil après radiothérapie et Proctectomie Pour Cancer du Rectum : Essai contrôlé randomisé

Sponsor

University Hospital, Rouen

Enrollment

188 participants

Start Date

Sep 25, 2025

Study Type

INTERVENTIONAL

Conditions

Rectal Cancer

Summary

This study aims to evaluate the efficacy of erectile rehabilitation with Sildenafil, in men treated with neoadjuvant proctectomy and radiotherapy for rectal cancer, in preventing long-term erectile dysfunction at 12 months post-operatively.

Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Placebo and a drug called Sildenafil for people with rectal cancer. The study is currently recruiting participants at 14 locations. People eligible for this study include men aged 18 Years to 70 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGSildenafil

Sildénafil during 10 months (50mg daily), start 30 days after surgery

OTHERPlacebo

1 platelet during 10 months (daily), start 30 days after surgery

Locations(14)

Chu Amiens

Amiens, France

Hopital Beauvais

Beauvais, France

Chu Besancon

Besançon, France

Aphp Bicetre

Bicêtre, France

Chu Bordeaux

Bordeaux, France

Institut Bordeaux Colorectal

Bordeaux, France

Chu Clermont-Ferrand

Clermont-Ferrand, France

Chu Lille

Lille, France

Institut Paoli-Calmettes

Marseille, France

Institut Du Cancer Montpellier

Montpellier, France

Aphp St Antoine

Paris, France

Aphp Hegp

Paris, France

Chu Rouen

Rouen, France

Chu Tours

Tours, France

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06123156

Related Trials

Safety of Mid and Low Rectal Cancer Surgery Without Dissection of the No.253 Lymph Node (S-M-O-O-T-H)

NCT061469468 locations

A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.

NCT050240973 locations

Total Meso-rectal Excision Versus Transanal Local Excision Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer

NCT040984711 location

Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome

NCT077328941 location

Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Tislelizumab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement

NCT071046042 locations