RecruitingNCT06123975

Adenomyosis Patients With Infertility and Immunological Factors

Study of the Role of Immunologic Factors in Adenomyosis Patients With Infertility

Sponsor

Peking University Third Hospital

Enrollment

200 participants

Start Date

Mar 1, 2024

Study Type

OBSERVATIONAL

Conditions

Adenomyosis

Summary

Infertile patients with adenomyosis who met the inclusion and exclusion criteria, after signing the informed consent form, the researchers recorded the clinical information of the patients and initiated the in vitro fertilization-embryo transfer (IVF-ET) procedure. Peripheral blood was collected on the day of embryo transfer. And if the pregnancy test was positive at 14 days after embryo transfer, peripheral blood was collected at 21 days after the transfer and every 2 weeks thereafter until 12 weeks of gestation. By analyzing the changes of immune cells and molecules in the peripheral blood of the patients, role of immune factors in infertility combined with adenomyosis was further explored.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Inclusion Criteria3

Patients were diagnosed as adenomyosis by transvaginal ultrasound scans (The criteria for sonographic diagnosis of adenomyosis are with 2 or more of the following: heterogeneous myometrial texture with the presence of globular asymmetric uterus, thickening of the anterior and posterior myometrial wall, irregular cystic areas within the myometrium);
≤ age ≤ 40 years old at first outpatient visit in our Reproductive Center;
with regular menstrual cycle.

Exclusion Criteria3

Patients with intrauterine adhesion, uterine malformation, submucosal leiomyoma, or ≥ 5.0 cm in diameter leiomyoma;
hydrosalpinx and systemic diseases;
patients with other endocrine severe diseases, immune diseases, tumors and abnormal chromosomes in either partner.

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Interventions

OTHERVenous blood collection

Peripheral blood was collected on the day of embryo transfer. And if the pregnancy test was positive at 14 days after embryo transfer, peripheral blood was collected at 21 days after the transfer and every 2 weeks thereafter until 12 weeks of gestation.