RecruitingNCT06129552

Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps


Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

300 participants

Start Date

Dec 19, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected patient samples.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • Patients over the age of 18
  • Males and females

Exclusion Criteria4

  • CRSwNP
  • AR
  • Smoker, or < 1-year ex-smoker
  • Underlying systematic pathology (Morbus Wegener or Churg Strauss Syndrome for example)

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Interventions

PROCEDUREConchotomy, aesthetic nose surgery or functional endoscopic sinus operation

Conchotomy involves the reduction or removal of hypertrophic nasal turbinates, aesthetic nose surgery is a surgical procedure that aims to enhance the appearance of the nose, while functional endoscopic sinus surgery is a minimally invasive procedure focused on treating sinus conditions by removing obstructions and improving sinus drainage.


Locations(1)

Peter Hellings

Leuven, Belgium

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NCT06129552


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