RecruitingNot ApplicableNCT06130787

Value of Biological Age, in Addition to Individual Frailty, for Personalising the Management of Cancer Treated with Targeted Therapy

Value of Biological Age, in Addition to Individual Frailty, for Personalising the Management of Cancer Treated with Targeted Therapy: the Model of Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitors.


Sponsor

University Hospital, Clermont-Ferrand

Enrollment

321 participants

Start Date

Nov 17, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

French prospective multicenter, open-label study involving newly diagnosed CML patients. Two assessments will be performed during the follow-up of these patients: individual frailty using geriatric tools and individual biological aging determined by DNA methylation analysis.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether measuring a patient's 'biological age' (how old the body is functioning compared to actual age) alongside standard frailty assessments can better guide treatment decisions for people newly diagnosed with chronic myeloid leukemia (CML). CML is a type of blood cancer. Patients are treated with drugs called tyrosine kinase inhibitors (TKIs), and this study aims to personalize care based on biological rather than just chronological age. **You may be eligible if...** - You are 18 or older - You have been newly diagnosed with CML in the chronic (early, stable) phase - Your diagnosis was made within the last 3 months - You read and understand French - You have not yet started TKI therapy **You may NOT be eligible if...** - Your CML is in an advanced phase (accelerated or blast phase) - You have already started CML treatment - You are pregnant or breastfeeding - You are under legal guardianship or in judicial custody Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALBlood and bone marrow sample

Individual biological aging determined by DNA methylation analysis will be assessed at D0, M3 and M12. An optional bone marrow sample will be taken during the myelogram performed at diagnosis. Individual fragility and quality of life will be assessed using geriatric tools at D0, M6, M12, M24 and M36


Locations(17)

CHU Annecy-Genevois

Annecy, France

Institut Bergonié

Bordeaux, France

CHU Caen

Caen, France

CHU de Clermont-Ferrand

Clermont-Ferrand, France

CHU Créteil

Créteil, France

CHU Grenoble Alpes

Grenoble, France

Centre Hospitalier Emile Roux

Le Puy-en-Velay, France

CHRU Lille

Lille, France

CHU Limoges

Limoges, France

Centre Léon Bérard

Lyon, France

Institut Paoli-Calmettes

Marseille, France

CHU Nancy

Nancy, France

Groupe Hospitalier Paris Saclay - Site de Bicêtre

Paris, France

CHU Rennes

Rennes, France

CHU Saint-Etienne

Saint-Etienne, France

Institut Universitaire du Cancer de Toulouse - Oncopole

Toulouse, France

CHU Versailles

Versailles, France

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NCT06130787


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