Sulfasalazine in Patients With Metastatic Colorectal Cancer

This trial tests whether adding sulfasalazine — an anti-inflammatory drug already used for conditions like rheumatoid arthritis — to standard chemotherapy can improve outcomes for patients with stage IV (metastatic) colorectal cancer. Sulfasalazine may help by blocking certain pathways that help cancer cells survive. **You may be eligible if...** - You are 18 to 65 years old with confirmed stage IV (metastatic) colorectal cancer - You have adequate liver, kidney, and blood count function - You are not currently receiving other cancer treatments that would interfere - Women of childbearing age must be willing to use contraception **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have another active cancer - You are allergic to sulfasalazine or its components - You have kidney stones, severe vomiting, or severe diarrhea - You are taking blood thinners (like warfarin) - You have urinary or bowel obstruction - You already take sulfasalazine or mesalamine for inflammatory bowel disease Talk to your doctor to see if this trial is right for you.