Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
Randomized Intra-individually Controlled Double-blinded Trial Comparing Effect of Small Interfering RNA Against SPARC (siSPARC) Microneedle Patch Versus Small Interfering RNA Against SPARC and IL4-RA (siSPARC + siLR4A) Microneedle Patch on Appearance of Post-surgical Scars
National Skin Centre
50 participants
Nov 14, 2023
INTERVENTIONAL
Conditions
Summary
This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches. These are patches comprising short microneedles embedded with hydrolysed RNA (siRNAs).
Eligibility
Inclusion Criteria5
- Adult
- Age 21-75
- weeks (+/- 7 days) after surgical operation with incision into the dermis
- Post-stitch removal when stitches were applied
- Wound closure/union achieved
Exclusion Criteria5
- Pregnant or lactating participant
- Participants with wound infection
- Participants assessed to be uncooperative or unable to self-administer the interventions
- Participants with known contact allergy to ingredients in the patch formulation (comprising hyaluronic acid, siRNA and glue) and/or isopropyl alcohol
- Participants who are unable to personally consent (for e.g., cognitively impaired)
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Interventions
siSPARC + siLR4A microneedle patch
siSPARC microneedle patch
Locations(1)
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NCT06138964