RecruitingPhase 2NCT06138990

Pharmacoscopy-guided Clinical Standard-of-care in r/r AML

Pharmacoscopy-guided Clinical Standard-of-care in Relapsed/Refractory Acute Myeloid Leukemia, a Randomized Phase-2 Clinical Trial


Sponsor

ETH Zurich

Enrollment

88 participants

Start Date

Sep 2, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

With an overall survival of below 12 months, the outcome of relapsed/refractory AML (RR AML) is poor, making it a critical challenge to identify effective therapies at this stage. The RAPID-01 trial aims to show for the first time in a randomized and controlled clinical trial that Pharmacoscopy (PCY), a functional precision medicine platform, helps improve clinical standard-of-care treatment selection for patients suffering from relapsed/refractory AML.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether using a high-tech drug sensitivity test called pharmacoscopy — which directly tests a patient's own cancer cells against dozens of drugs in the lab — can guide treatment decisions for people with relapsed or refractory AML (acute myeloid leukemia), a fast-moving blood cancer that has stopped responding to standard therapies. **You may be eligible if...** - You are between 18 and 70 years old - You have AML that has relapsed (come back) or is refractory (not responding) based on standard criteria - You are healthy enough to receive intensive chemotherapy - You have given written informed consent **You may NOT be eligible if...** - You have a subtype called acute promyelocytic leukemia (APL) - Your AML arose from chronic myeloid leukemia (CML blast crisis) - You are not fit enough for intensive chemotherapy - Your condition is too urgent to wait for the test results - The pharmacoscopy test could not be performed on your sample Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPharmacoscopy

Pharmacoscopy (PCY) is an image-based ex vivo drug testing platform developed by the Snijder lab at the ETH Zurich. PCY measures in the drug response of patient cells from small biopsies using automated microscopy and single-cell image analysis. PCY prioritizes treatments based on their specific efficacy against AML cells, while minimizing toxicity to healthy (non-malignant) cells in the patient biopsy.

DRUGClinical standard-of-care (physician's choice)

Clinical standard-of-care therapy for RR AML selected by the physician (physician's choice).


Locations(2)

Inselspital Bern

Bern, Canton of Bern, Switzerland

University Hospital Zurich

Zurich, Canton of Zurich, Switzerland

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NCT06138990


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