RecruitingNot ApplicableNCT06139627

Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy

Geriatric Assessment and Management (GAM) for Older Adults With Non-Small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy (GAM-CRT)


Sponsor

City of Hope Medical Center

Enrollment

180 participants

Start Date

May 21, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial tests how well a geriatric assessment (GA) with GA-directed treatment recommendations, compared to GA with usual care, works in identifying risk factors, reducing chemotherapy radiation toxicity and functional decline, and improving the overall quality of life in older patients with non-small cell lung cancer (NSCLC). Older patients with lung cancer undergoing chemotherapy are at an increased risk of adverse outcomes including treatment toxicity and functional and physical consequences. This makes it very challenging for the physicians to balance the benefits against the risk of chemotherapy in older cancer patients. A geriatric assessment may be useful in identifying risk factors for chemotherapy radiation toxicity. Communicating these geriatric assessment findings and assessment-based recommendations to a patient's treating physicians may help them make more informed decisions about treatment options for patients. Making treatment decisions using GA-based recommendations may reduce adverse events and improve outcomes in patients receiving treatment for NSCLC.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates whether adding a comprehensive health assessment for older cancer patients — called a geriatric assessment — improves care and outcomes in adults 60 and older with inoperable non-small cell lung cancer (NSCLC) who are receiving chemotherapy and radiation together. **You may be eligible if...** - You are 60 or older - You have been diagnosed with unresectable (inoperable) non-small cell lung cancer - You are about to start a new cancer treatment at the participating site within the next 4–6 weeks - You are being treated at one of the participating study sites **You may NOT be eligible if...** - You are under 60 years old - Your lung cancer is resectable (can be surgically removed) - You are not being treated at a participating site - You are not planning to start a new treatment regimen Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBest Practice

Receive usual care

PROCEDUREBiospecimen Collection

Undergo blood and stool sample collection

OTHERCommunication Intervention

Receive GA assessment summary and assessment-based recommendations

OTHERComprehensive Geriatric Assessment

Complete GA

OTHERElectronic Health Record Review

Ancillary studies

OTHERSurvey Administration

Ancillary studies


Locations(3)

City of Hope Medical Center

Duarte, California, United States

University of Rochester

Rochester, New York, United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

View Full Details on ClinicalTrials.gov

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NCT06139627


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