RecruitingNot ApplicableNCT06142955

Transcranial Magnetic Stimulation (TMS) to Treat Depression in Autism Spectrum Disorder

Neuromodulation for Depression in Autism Spectrum Disorder


Sponsor

Yale University

Enrollment

60 participants

Start Date

Apr 30, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study will assess clinical and behavioral measures along with electroencephalogram (EEG), event-related potentials (ERPS), and eye-tracking (ET) prior to and following a single intermittent Theta Burst Stimulation (iTBS) session to provide preliminary insight into the potential of TMS as an intervention for depression in individuals with Autism Spectrum Disorder (ASD).


Eligibility

Min Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a brain stimulation technique called Transcranial Magnetic Stimulation (TMS) — which uses magnetic pulses directed at the brain — can help reduce depression in people with or without autism spectrum disorder (ASD). **You may be eligible if...** - You are between 18 and 40 years old - You have depression (with a significant score on a depression rating scale), with or without autism spectrum disorder - OR you have a diagnosis of autism spectrum disorder (including Asperger's or PDD-NOS) with or without depression - Your medications have been stable for at least two weeks - You are willing to participate in EEG and eye-tracking tests **You may NOT be eligible if...** - You have had a serious head injury or brain illness - You have bipolar disorder or a psychotic condition - You have a history of seizures or epilepsy - You take medications that raise seizure risk - You have used alcohol or drugs in the past 24 hours - You have a history of substance abuse in the last 6 months - You are pregnant - You have metal in your body (e.g., shrapnel, implants) - You have had prior TMS treatment - You have an IQ below 80 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEMAGSTIM Rapid2 TMS system

The device will administer TMS pulses in bursts at fixed intervals for a total of 600 pulses over 190 seconds after first assessing the participants motor threshold (MT). During the sham stimulation condition, the TMS coil will be tilted 90° tangential to the scalp during the administration so that the orientation is not biologically active and will not elicit a muscle contraction. This sham condition will look and sound just like real TMS.


Locations(1)

Yale Psychiatric Hospital

New Haven, Connecticut, United States

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NCT06142955


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