Prescription of Letrozole for Uterine Myoma

This trial tests whether letrozole — a medication typically used to treat breast cancer — can help shrink uterine fibroids (noncancerous growths in the uterus) and reduce symptoms like heavy periods and pelvic pain in premenopausal women. **You may be eligible if...** - You are a woman between 21 and 53 years old - You have fibroids confirmed by ultrasound or MRI in the last 2 years - You have moderate-to-severe symptoms from your fibroids (heavy bleeding, pressure, pain) - You have regular menstrual cycles - You are willing to use non-hormonal contraception during the study **You may NOT be eligible if...** - You have a very large fibroid or a very large uterus - You have a fibroid that is mostly inside the uterine cavity - You have been hospitalized recently for fibroid symptoms - You recently had surgery or treatment for fibroids - You are pregnant, breastfeeding, or planning to become pregnant soon - You have osteoporosis or very low bone density - You have a history of breast cancer - You have severe liver disease - You have used hormonal therapies or aromatase inhibitors recently Talk to your doctor to see if this trial is right for you.