RecruitingNCT06146608

Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption

Sponsor

Cornell University

Enrollment

120 participants

Start Date

Jan 15, 2023

Study Type

OBSERVATIONAL

Conditions

Iron Overload Anemia, Iron Deficiency

Summary

The FeMicrobiome study will evaluate gut microbiome features and their relationships with dietary iron absorption in healthy adults. The investigators hypothesize that (1) the gut microbiota can be shaped by the heme and non-heme Fe content of the diet and that (2) this will influence individual variation in dietary Fe absorption.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria7

Healthy adults
Age between 18- 40y
Non-smoking
Not currently taking vitamin, mineral, prebiotic, and probiotic supplements.
Females: premenopausal and not pregnant or lactating
No preexisting medical complications (such as eating disorders, hemoglobinopathies, malabsorption diseases, steroid use, substance abuse history, or taking medications known to influence iron homeostasis)
Body mass index (BMI) between 18 - 27 kg/m2.

Exclusion Criteria7

BMI \<18 or \> 27 kg/m2,
Age \<18 y or \> 40y,
Smoking
Pregnancy, lactating
Have gastrointestinal disorders/malabsorption diseases/hemoglobinopathies/dietary restrictions/steroid use/ medication use of medications known to impact iron status, iron utilization or inflammatory status
Currently take vitamin, mineral, prebiotic, and probiotic supplements.
Recently received antibiotic treatment

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