RecruitingPhase 3NCT06148792

A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria

A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria - TAfenoquine DOsing REvised


Sponsor

Menzies School of Health Research

Enrollment

1,090 participants

Start Date

May 10, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to assess the efficacy and safety or a revised weight band tafenoquine dose in vivax malaria patients. The main question\[s\] it aims to answer are: * is a revised weight-based TQ regimen (TQRevised: target dose 7.5mg/kg) non-inferior to high dose primaquine (7mg/kg over 7 days) * is a revised weight-based TQ regimen (TQRevised: target dose 7.5mg/kg) superior to fixed dose tafenoquine (300mg) * is the tolerability and safety of TQRevised acceptable * is TQRevised acceptable and feasible Participants will receive a tafenoquine target dose 7.5mg/kg in weight bands. Researchers will compare this to patients receiving a fixed dose tafenoquine and high dose primaquine to see if safe and effective.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Primaquine and a drug called Tafenoquine for people with vivax malaria. The study is currently recruiting participants at 4 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTafenoquine

oral treatment

DRUGPrimaquine

oral treatment


Locations(4)

Dr Marcus Lacerda

Manaus, Brazil

Arba Minch General Hospital

Arba Minch, Ethiopia

Puskesmas Hanura

Hanura, Indonesia

Dr Moses Laman and Dr Brioni Moore

Alexishafen, Papua New Guinea

View Full Details on ClinicalTrials.gov

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NCT06148792


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