RecruitingNot ApplicableNCT06155682

TMS for Inhibition Enhancement in Schizophrenia

Cognitive and Neural Correlates of TMS Motor Intracortical Inhibition in Schizophrenia

Sponsor

University of Maryland, Baltimore

Enrollment

34 participants

Start Date

Feb 2, 2026

Study Type

INTERVENTIONAL

Conditions

Schizophrenia

Summary

This study purpose is to perform a pilot mechanistic trial repetitive transcranial magnetic stimulation (rTMS) clinical trial in 34 people with schizophrenia (Sz). The trial will evaluate whether inhibitory 1 Hertz (Hz) rTMS targeting motor cortex can increase brain inhibition reflected in a decrease in the short-interval intracortical inhibition (SICI) score from pre-to-post-treatment. We will also collect preliminary data on the effect of rTMS on the resting functional connectivity of the motor cortex and other brain regions and the relationship of change in SICI to change in cognitive performance

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is using a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to target a part of the brain involved in inhibition and self-control in people with schizophrenia. Researchers hope this could improve symptoms that are often hard to treat with medication alone. **You may be eligible if...** - You are between 18 and 45 years old - You have a formal diagnosis of schizophrenia (confirmed using a structured clinical interview) - You are able to understand the study and provide voluntary consent **You may NOT be eligible if...** - You have metal implants in your head or other contraindications to TMS - You do not meet the diagnostic criteria for schizophrenia - You are unable to provide informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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