RecruitingNCT06156670

Russian Registry of Endovascular Closure of PFO

Russian Registry of Endovascular Closure of Patent Foramen Ovale


Sponsor

National Medical Research Center for Cardiology, Ministry of Health of Russian Federation

Enrollment

700 participants

Start Date

Dec 1, 2023

Study Type

OBSERVATIONAL

Summary

The study will include all patients over 18 years of age who underwent endovascular closure of patent foramen ovale in medical centers in the Russian Federation, who gave written informed consent to the closure and provided personal data as part of inpatient medical care. The project participants will be 29 medical centers in the Russian Federation, where endovascular closure of patent foramen ovale is performed.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria5

  • Patients with an ischemic event (cryptogenic ischemic stroke, transient ischemic attack, embolism of other organs and systems) associated with a PFO;
  • Presence of an open oval confirmed by ultrasound diagnostic methods;
  • Age of patients from 18 years;
  • Life expectancy of at least 1 year;
  • Signed informed consent for endovascular closure of a PFO.

Exclusion Criteria8

  • Inability to receive antiplatelet therapy;
  • Presence of acute inflammatory diseases;
  • Acute stage of cerebral circulatory failure (30 days);
  • Myocardial infarction or aortocoronary bypass surgery within the previous 30 days;
  • Carotid or vertebral artery dissection;
  • Severe cardiac valve pathology;
  • Presence of blood clots in the cardiac cavities;
  • Refusal of the patient to participate in the study.

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Interventions

DEVICEPFO closure

The operation of endovascular closure of PFO is performed on X-ray angiographic devices with digital processing of X-ray images. Endovascular closure of a PFO will be performed by femoral venous access using the following instruments: diagnostic catheter, diagnostic guidewire, high-stiffness guidewire for delivery system, interatrial septum occluders of PFO, UNI, ASD types. Preoperative preparation and control of device implantation will be performed using modern echocardiographic equipment.


Locations(1)

National Medical Research Center for Cardiology, Ministry of Health of Russian Federation

Moscow, Russia

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NCT06156670