RecruitingNCT06156774

SARcopenia and Simplified Geriatric Assessment in Lymphoma Patients Undergoing CAR-T Cell Therapy: the FIL_SAR-CAR Project

Sponsor

Fondazione Italiana Linfomi - ETS

Enrollment

130 participants

Start Date

Apr 18, 2024

Study Type

OBSERVATIONAL

Conditions

Non-hodgkin Lymphoma,B Cell

Summary

This is a multicenter prospective observational study lead by the FIL on sarcopenia and sGA as possible predictors of efficacy and toxicity outcomes in patients undergoing CAR-T cells treatment.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Adult patients (≥ 18 years old).
Patients with B-cell non-Hodgkin Lymphoma scheduled to received CAR-T cell product according to Agenzia Italiana del Farmaco (AIFA) indications and technical data sheet of the drug
Availability of a 18F-FDG PET/CT scan or a full dose CT scan (without contrast media) pre-treatment with CART
Written informed consent voluntarily provided

Exclusion Criteria1

Patients not fulfilling the eligibility criteria

Interventions

OTHERChimeric Antigen Receptor T-cells (CAR-T) therapy

Patients will be treated with CAR-T cell product as per routine clinical practice.

Locations(21)

A.O. SS. Antonio e Biagio e Cesare Arrigo - S.C.D.U. Ematologia

Alessandria, Italy

AOU Ospedali Riuniti - Clinica di Ematologia

Ancona, Italy

Azienda Ospedaliera S .Giuseppe Moscati - S.C. Ematologia e Trapianto emopoietico

Avellino, Italy

IRCCS Centro di Riferimento Oncologico di Aviano - Divisione di Oncologia e dei Tumori immuto-correlati

Aviano, Italy

ASST Spedali Civili di Brescia - S.C. Ematologia

Brescia, Italy

Ospedale di Castelfranco Veneto - Oncoematologia IOV

Castelfranco Veneto, Italy

Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia

Florence, Italy

ASST Grande Ospedale Metropolitano Niguarda - S.C. Ematologia

Milan, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano - Ematologia

Milan, Italy

Istituto Scientifico San Raffaele - Unità Linfomi - Dipartimento Oncoematologia

Milan, Italy

A.O. Ospedali Riuniti Villa Sofia-Cervello - Divisione di Ematologia

Palermo, Italy

Ospedale S. Maria della Misericordia - Ematologia

Perugia, Italy

Ospedale Guglielmo da Saliceto - U.O. Ematologia

Piacenza, Italy

AOU Pisana - U.O. Ematologia

Pisa, Italy

Azienda Unità Sanitaria Locale-IRCCS - Arcispedale Santa Maria Nuova - Ematologia

Reggio Emilia, Italy

Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica S. Cuore - Ematologia

Roma, Italy

Policlinico Umberto I - Università "La Sapienza" - Istituto Ematologia -Dipartimento di Medicina Traslazionale e di Precisione

Roma, Italy

A.O.U. Citta della Salute e della Scienza di Torino - S.C. Ematologia

Torino, Italy

Azienda Sanitaria Universitaria Friuli Centrale (ASU FC) - Clinica di Ematologia

Udine, Italy

AOU Integrata di Verona - U.O. Ematologia

Verona, Italy

ULSS 8 Berica - Ospedale S. Bortolo - Ematologia

Vicenza, Italy

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NCT06156774

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