Autologous CAR-T Cells Targeting B7-H3 in PDAC

This study is testing a new type of immune cell therapy called CAR-T cells, engineered to target a protein called B7-H3 found on pancreatic cancer cells. These specially modified immune cells are taken from the patient, altered in a lab to recognize and attack the tumor, and then infused back into the patient. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with pancreatic ductal adenocarcinoma (a type of pancreatic cancer) confirmed by tissue biopsy or pathology - Your overall health meets the required performance status - You are willing and able to provide informed consent - If you are of childbearing potential, you agree to use contraception **You may NOT be eligible if...** - You do not have confirmed pancreatic ductal adenocarcinoma - Your overall health or organ function does not meet the required thresholds - You are unwilling to comply with contraception requirements Talk to your doctor to see if this trial is right for you.