RecruitingPhase 2NCT06158386

Chidamide Combined With Linperlisibon for the Treatment of Refractory/Relapsed Follicular Lymphoma

A Multicenter, Prospective, Single-arm Clinical Study on the Treatment of Refractory/Relapsed Follicular Lymphoma (R/RFL) With Chidamide Combined With Linperlisib


Sponsor

The First Affiliated Hospital of Xiamen University

Enrollment

33 participants

Start Date

Nov 22, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

To observe the safety and efficacy of Chidamide combined with Linperlisib in the treatment of refractory and relapsed follicular lymphoma.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of two drugs — chidamide (an epigenetic drug that affects how genes are expressed) and linperlisibon (a PI3K inhibitor that targets cancer cell growth) — in patients with follicular lymphoma (a slow-growing type of blood cancer) that has stopped responding to previous treatments. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with follicular lymphoma (Grade 1 to 3a) - You have already received at least two prior treatments, with at least one including an anti-CD20 antibody drug (such as rituximab) - Your cancer has relapsed (come back) or is no longer responding to treatment - Your expected survival is more than 3 months - Your general health is adequate for treatment **You may NOT be eligible if...** - You have not previously received at least two treatments - Your lymphoma has transformed into a more aggressive type - Your organ function or overall health does not meet the requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGChidamide combined with Linperlisib

Specified dose on specified days: Cedarbenzamide (C) 20mg orally twice weekly, Limplica (L) 80mg once daily, 2 weeks on 2 weeks off, Repeat on day 28.


Locations(1)

Bing Xu

Xiamen, Fujian, China

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NCT06158386


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