RecruitingNot ApplicableNCT06159023

Conventional Bronchoscope With BAL vs. Thin Bronchoscope With BW to Diagnose Pulmonary TB

Bronchoalveolar Lavage Using a Conventional Bronchoscope vs. Bronchial Washing Using a Thin Bronchoscope to Diagnose Pulmonary Tuberculosis: a Prospective Randomized Trial

Sponsor

Pusan National University Hospital

Enrollment

132 participants

Start Date

Dec 15, 2023

Study Type

INTERVENTIONAL

Conditions

Tuberculosis, Pulmonary

Summary

This study aims to compare the diagnostic yield of bronchoalveolar lavage (BAL) using a thick conventional bronchoscope and bronchial washing (BW) using a thin bronchoscope in the diagnosis of pulmonary tuberculosis.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

participants age > 17 years with suspected pulmonary TB
possible active pulmonary TB evident on chest radiography or CT scan
negative AFB smear results (using two consecutive self-expectorated sputum)
negative TB-PCR results (using one self-expectorated sputum)
inability to produce self-expectorated sputum

Exclusion Criteria3

a request for empirical TB treatment rather than bronchoscopy
suspect pulmonary TB lesions that are difficult to target for BAL or BW (e.g., multiple discrete tiny nodules)
contra-indication of bronchoscopy (e.g., bleeding tendency, hypoxemia requiring oxygen, or uncontrolled cardio/cerebrovascular disease)

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Interventions

DEVICEbronchial washing using a thin bronchoscope

For intervention, we plan to perform bronchial washing using a thin bronchoscope instead of bronchoalveolar lavage with the conventional thick bronchoscope to diagnose pulmonary TB.