RecruitingPhase 3NCT06159335

18F-FLUC PET/MR in Patients With Brain Mets

Use of 18F-Fluciclovine PET for Discerning Tumor From Treatment Change in Patients With Brain Metastases Undergoing Immunotherapy

Sponsor

University of Wisconsin, Madison

Enrollment

30 participants

Start Date

Jan 10, 2024

Study Type

INTERVENTIONAL

Conditions

Brain Metastasis Radiation Therapy Immunotherapy, Active

Summary

The goal of this clinical trial is to use new imaging methods to help in finding out whether the imaging shows that there is a tumor in people with a brain metastasis. The main question it aims to answer is whether positron emission tomography (PET) and magnetic resonance imaging (MRI) find cancerous tissue better than other types of imagining. Participants will undergo a single PET/MRI scan, followed by a separate MRI scan with a tracer. Study participation will last about 3 hours.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of PET/MRI brain scan using a tracer called 18F-FLUC in patients who have cancer that has spread to the brain (brain metastases). The scan may help doctors better distinguish between active tumor and treatment-related changes (such as radiation damage), which can look similar on standard imaging. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with brain metastases and have at least one visible lesion on MRI - You have received radiation therapy for brain metastases in the past 2 years - You are currently receiving cancer treatment - You are able and willing to provide informed consent **You may NOT be eligible if...** - You are under 18 years old - You have not had prior radiation treatment for brain metastases - You do not have a confirmed brain metastasis on MRI - You are unable to provide consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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